About

Row

About Me

I joined the Funai lab in March 2023 as a Postdoctoral Research Associate in the Molecular Medicine Program at the University of Utah, focusing on understanding X-linked Alport Syndrome - a rare hereditary condition that results in the loss of glomerular, ocular, and cochlear basement membranes and premature kidney failure. I received my Ph.D. in Kinesiology with an emphasis in Human Physiology at the University of Massachusetts Amherst. My dissertation work focused on the direct effects of cigarette smoke on mitochondrial function in muscle, heart, and vascular tissues. In my free time, I enjoys exploring the natural beauty of Utah with my wife, Rachel, and his daughters, Allie and Kyra, trail running, smoking my family-favorite BBQ brisket and ribs, watching/playing baseball, and traveling/visiting my family back home in Houston, TX.

Row

Expertise and Skills

I have skills in data analysis using open-source platforms (mainly R, RStudio, and Shiny). I am self-taught in data analysis tasks (hypothesis testing, A/B testing, frequentist and Bayesian methods) and have some experience in bioinformatics data processing and analysis (RNAseq using Bioconductor packages).

I also have experience in developing Shiny applications, dashboards, and interactive presentations. As part of my postdoctoral training, I was the sole developer of 2 Shiny applications: one to automate the measurment of protein concentration following a BCA assay (found here) and a second to improve post-processing of ATP production measurements using a fluorometric-based assay (found here). In addition to these applications, I developed a semi-automated workflow using Excel and R to improve post-processing of mitochondrial respiration data, as well as a standard analysis workflow of statistical methodology and data visualization using RMarkdown (found here). Last, I created an interactive dashboard using a combination of Flexdashboard, R Shiny, and ggiraph to display all of the data I collected during my Ph.D. dissertation projects (found here). All of these data are freely available and available on my GitHub.

Row

Why R?

I taught myself R for myriad reasons. First, I was a poor grad student in need of a good (free) statistical analysis program that could do complex analysis (i.e., dose-response curves and Michaelis-Menten kinetics), more modern nonparapetric analyses (ART ANOVA), and preferrably, one that could also handle the generation of nice visuals. Most options that could handle these needs were either too expensive or unavailable for use at my university. Thus, I began the process of teaching myself R. I began by performing simple data anlysis (t-tests and ANOVAS) and tidying tasks using the Tidyverse, then increasing the complexity of my tasks to kinetics analyses, Shiny apps, and dashboard generation.

Second, I strongly believe in the principles that surround R and the R community - namely the promotion of free and open-source information to drive decision making. I strongly believe that the data and information generated from complex scientific endeavors has no benefit to anybody if it is sheltered, hidden, or inaccessible by means such as gatekeeping and/or paywalls.

Third, I recognize that while I maintain a strong expertise in biological sciences and data analysis, I am still only human. I must acknowledge that, at times, I am prone to making errors in my judgement and analysis, and my knowledge is limited to only the things that I know. Therefore, it is important that, in the cases where I do err, that these mistakes are able to be improved or fixed to allow for better interpretation of these results. As a scientist and general problem solver, correction of errors in my data analysis methods will only lead to beneficial outcomes in the problems that I am trying to solve, thereby generating the best outcome possible.

Row

Publications

Column

First Author

Title

Author

Journal

Year

Citations

A Platform for Mitochondrial Profiling in Enriched Kidney Segments Under Thermodynamic Control

ST Decker, PC Opurum, RH Choi, VL Paula, AS Kurian, D Stewart,

bioRxiv

2025

0

Mitochondrial membrane lipids in the regulation of bioenergetic flux

ST Decker, K Funai

Cell metabolism

2024

21

Effects of cigarette smoke on in situ mitochondrial substrate oxidation of slow-and fast-twitch skeletal muscles

ST Decker, AA Matias, ST Bannon, JP Madden, N Alexandrou-Majaj,

Life Sciences

2023

14

The receptor for advanced glycation end products (RAGE) is involved in mitochondrial function and cigarette smoke-induced oxidative stress

OS Kwon, ST Decker, J Zhao, JR Hoidal, T Heuckstadt, KA Sanders,

Free Radical Biology and Medicine

2023

13

Effects of acute cigarette smoke concentrate exposure on mitochondrial energy transfer in fast-and slow-twitch skeletal muscle

ST Decker, N Alexandrou-Majaj, G Layec

Biochimica et Biophysica Acta (BBA)-Bioenergetics

2023

5

Tissue-specific mitochondrial toxicity of cigarette smoke concentrate: consequence to oxidative phosphorylation

ST Decker, AA Matias, AE Cuadra, ST Bannon, JP Madden, ME Erol,

American Journal of Physiology-Heart and Circulatory Physiology

2023

2

Skeletal muscle mitochondrial adaptations induced by long-term cigarette smoke exposure

ST Decker, OS Kwon, J Zhao, JR Hoidal, TP Huecksteadt, RS Richardson,

American Journal of Physiology-Endocrinology and Metabolism

2021

22

Column

Co-Author

Title

Author

Journal

Year

Citations

Combined sedentarism and high-fat diet induce early signs of kidney injury in C57BL/6J mice

PC Opurum, ST Decker, D Stuart, AD Peterlin, VL Paula, P Siripoksup,

American Journal of Physiology-Renal Physiology

2025

0

Cardiolipin deficiency disrupts electron transport chain to drive steatohepatitis

MJ Brothwell, G Cao, JA Maschek, AM Poss, AD Peterlin, L Wang,

bioRxiv

2025

0

Repeatability of alkaline inorganic phosphate quantification in the skeletal muscle using 31P‐magnetic resonance spectroscopy at 3 T

AA Matias, CF Serviente, ST Decker, ME Erol, G Giuriato, Y Le Fur,

NMR in Biomedicine

2024

3

Mitochondrial free radicals contribute to cigarette smoke condensate-induced impairment of oxidative phosphorylation in the skeletal muscle in situ

ST Bannon, ST Decker, ME Erol, R Fan, YT Huang, S Chung, G Layec

Free Radical Biology and Medicine

2024

1

From heart to muscle: pathophysiological mechanisms underlying long-term physical sequelae from SARS-CoV-2 infection

C Serviente, ST Decker, G Layec

Journal of Applied Physiology

2022

43

Sampling arterial input function (AIF) from peripheral arteries: comparison of a temporospatial-feature based method against conventional manual method

X Li, CC Conlin, ST Decker, N Hu, M Mueller, L Khor, C Hanrahan,

Magnetic resonance imaging

2019

3

Talks

Connecting the Dots of the Power Grid: Assessing mitochondrial membrane potential and ADP/ATP translocase activity in permeabilized skeletal muscle fiber bundles

UMass Kinesiology Seminar Series

Amherst, Massachusetts

2021

The Physiological Role of Sirtuins: A Target for Aging or More Hype?

UMass Kinesiology Seminar Series

Amherst, Massachusetts

2019

Effects of Tetrahydrobiopterin on Limb Blood Flow and Muscle Metabolism in Patients with COPD

ISMRM Annual Meeting

Montreal, Quebec

2019

Effects of High-Intensity Interval Training on Postprandial Lipemia and Glycemia

Texas ACSM

College Station, Texas

2016

Effects of Hot and Temperate Environments on Executive Function Tasks During Moderate and Intense Exercise

SFASU Undergraduate Research Conference

Nacogdoches, Texas

2014

Teaching

Row

University of Utah

Biol 2420 - Human Physiology*

Row

University of Massachusetts Amherst

KIN 272 - Anatatomy and Physiology II*
Kin 470 - Exercise Physiology Lab
KIN 270 - Anatatomy and Physiology I Lab
Kin 570 - Advanced Exercise Physiology
Kin 110 - Human Performance and Nutrition

Row

Stephen F. Austin State University

Kin 100 - Physical Fitness Concepts and Activities*
KIN 120 - Foundations of Kinesiology*
KIN 200 - Fitness Activites for Life*

Row

American Red Cross

American Red Cross CPR and Lifeguarding Instructor*

Row

* Denotes Instructor of Record

CV

---
title: "<b>Stephen Decker, Ph.D., ACSM-RCEP</b>"
output: 
  flexdashboard::flex_dashboard:
    orientation: rows
    vertical_layout: scroll
    includes:
      after_body: ./data/includes/footer.html
    social: menu
    source_code: embed
    self_contained: FALSE
    css: ./data/includes/css_setup.css
    theme: readable
    output: html_document
---


```{r setup, include=FALSE, warning=FALSE}

```

<style>

.sidebar { overflow: auto; padding-top:10%}

.chart-shim {
    overflow-y: scroll;
    }

</style>

<style type="text/css"> .sidebar { overflow: auto; padding-top:10%; text-align:"center"} </style>

# About


## Column {.sidebar data-width="270"}

###

```{r, img-with-knitr, echo=FALSE, fig.align='center', out.extra='class="myimg"'}

knitr::include_graphics("data/images/Stephen_Decker.png")
```

### Connect with me
`r fontawesome::fa("location-dot")` Salt Lake City, Utah
<br>
`r fontawesome::fa("linkedin")` [<span style="color:#333333">Stephen Decker</span>](https://www.linkedin.com/in/deckerst/)
<br>
`r fontawesome::fa("bluesky")` [<span style="color:#333333">decker-st.bsky.social</span>](https://bsky.app/profile/decker-st.bsky.social)
<br>
`r fontawesome::fa("twitter")` [<span style="color:#333333">@decker_st</span>](https://twitter.com/decker_st)
<br>
`r fontawesome::fa("github")` [<span style="color:#333333">stdecker</span>](https://github.com/sdecker4)
<br>
`r icons::academicons("google-scholar")` [<span style="color:#333333">Google Scholar</span>](https://scholar.google.com/citations?user=NVkoEucAAAAJ&hl=en)
<br>
`r icons::academicons("pubmed")` [<span style="color:#333333">PubMed</span>](https://pubmed.ncbi.nlm.nih.gov/?term=Decker+ST&cauthor_id=34121449)
<br>
`r fontawesome::fa("orcid")` [<span style="color:#333333">ORCID</span>](https://orcid.org/0000-0001-5867-1294)

## Row

###

#### About Me

I joined the Funai lab in March 2023 as a Postdoctoral Research Associate in the Molecular Medicine Program at the University of Utah, focusing on understanding X-linked Alport Syndrome - a rare hereditary condition that results in the loss of glomerular, ocular, and cochlear basement membranes and premature kidney failure. I received my Ph.D. in Kinesiology with an emphasis in Human Physiology at the University of Massachusetts Amherst. [My dissertation work](https://stdecker.github.io/Dissertation_Dashboard/) focused on the direct effects of cigarette smoke on mitochondrial function in muscle, heart, and vascular tissues. In my free time, I enjoys exploring the natural beauty of Utah with my wife, Rachel, and his daughters, Allie and Kyra, trail running, smoking my family-favorite BBQ brisket and ribs, watching/playing baseball, and traveling/visiting my family back home in Houston, TX.

## Row

###

#### Expertise and Skills

I have skills in data analysis using open-source platforms (mainly R, RStudio, and Shiny). I am self-taught in data analysis tasks (hypothesis testing, A/B testing, frequentist and Bayesian methods) and have some experience in bioinformatics data processing and analysis (RNAseq using Bioconductor packages). 
<br>
<br>
I also have experience in developing Shiny applications, dashboards, and interactive presentations. As part of my postdoctoral training, I was the sole developer of 2 Shiny applications: one to automate the measurment of protein concentration following a BCA assay ([found here](https://github.com/stdecker/ProteinQuantification-BCA-Western)) and a second to improve post-processing of ATP production measurements using a fluorometric-based assay ([found here](https://github.com/stdecker/FM4_ATP_Analysis)). In addition to these applications, I developed a semi-automated workflow using Excel and R to improve post-processing of mitochondrial respiration data, as well as a standard analysis workflow of statistical methodology and data visualization using RMarkdown ([found here](https://github.com/stdecker/Oroboros-O2K-Analysis])). Last, I created an interactive dashboard using a combination of Flexdashboard, R Shiny, and ggiraph to display all of the data I collected during my Ph.D. dissertation projects ([found here](https://stdecker.github.io/Dissertation_Dashboard/)). All of these data are freely available and available on my [GitHub](https://github.com/stdecker).

## Row

###

#### Why R?

I taught myself R for myriad reasons. First, I was a poor grad student in need of a good (free) statistical analysis program that could do complex analysis (i.e., dose-response curves and Michaelis-Menten kinetics), more modern nonparapetric analyses (ART ANOVA), and preferrably, one that could also handle the generation of nice visuals. Most options that could handle these needs were either too expensive or unavailable for use at my university. Thus, I began the process of teaching myself R. I began by performing simple data anlysis (t-tests and ANOVAS) and tidying tasks using the Tidyverse, then increasing the complexity of my tasks to kinetics analyses, Shiny apps, and dashboard generation. 
<br>
<br>
Second, I strongly believe in the principles that surround R and the R community - namely the promotion of free and open-source information to drive decision making. I strongly believe that the data and information generated from complex scientific endeavors has no benefit to anybody if it is sheltered, hidden, or inaccessible by means such as gatekeeping and/or paywalls. 
<br>
<br>
Third, I recognize that while I maintain a strong expertise in biological sciences and data analysis, I am still only human. I must acknowledge that, at times, I am prone to making errors in my judgement and analysis, and my knowledge is limited to only the things that I know. Therefore, it is important that, in the cases where I do err, that these mistakes are able to be improved or fixed to allow for better interpretation of these results. As a scientist and general problem solver, correction of errors in my data analysis methods will only lead to beneficial outcomes in the problems that I am trying to solve, thereby generating the best outcome possible.

## Row

```{r}
library(slickR)

slickR(
    list.files("data/images/slide/", full.names = TRUE)) +
  settings(dots = T, autoplay = T, autoplaySpeed = 5000)

```


# Publications


```{r include=FALSE}
library(stringr)
library(dplyr)
library(scholar)
library(flextable)
library(ftExtra)

pubs <- scholar::get_publications("NVkoEucAAAAJ&hl", flush = T) %>% 
  dplyr::mutate(author = author %>% 
                  as.character %>% 
                  stringr::str_trim(),
                first_author = dplyr::case_when(stringr::str_starts(author, "ST Decker") ~ TRUE,
                                         TRUE ~ FALSE)) %>% 
  dplyr::arrange(desc(year))

pubs$first_author[which(pubs$title == "The receptor for advanced glycation end products (RAGE) is involved in mitochondrial function and cigarette smoke-induced oxidative stress")] <- TRUE

pubs$author <- stringr::str_replace(pubs$author, "ST Decker", "**ST Decker**")

fa_list <- subset(pubs, first_author == TRUE)


coa_list <- subset(pubs, first_author == FALSE)

```

## Column

###

#### First Author

```{r}
fa_list$year <- as.character(fa_list$year)

flextable::flextable(fa_list[c(1:3, 6, 5)]) |>
  flextable::autofit() |> 
  flextable::theme_vanilla() |>
  flextable::italic(j = 3) |> 
  flextable::set_header_labels("title" = 'Title', 'author' = 'Author', 'journal' = 'Journal', 'year' = 'Year', 'cites' = 'Citations') %>%
  ftExtra::colformat_md()

```

## Column

###

#### Co-Author

```{r}
coa_list$year <- as.character(coa_list$year)

flextable::flextable(coa_list[c(1:3, 6, 5)]) |>
  flextable::autofit() |> 
  flextable::theme_vanilla() |>
  flextable::italic(j = 3) |> 
  flextable::set_header_labels("title" = 'Title', 'author' = 'Author', 'journal' = 'Journal', 'year' = 'Year', 'cites' = 'Citations') %>%
  ftExtra::colformat_md()

```


# Talks

###

#### Connecting the Dots of the Power Grid: Assessing mitochondrial membrane potential and ADP/ATP translocase activity in permeabilized skeletal muscle fiber bundles

UMass Kinesiology Seminar Series

Amherst, Massachusetts

2021



#### The Physiological Role of Sirtuins: A Target for Aging or More Hype?

UMass Kinesiology Seminar Series

Amherst, Massachusetts

2019



#### Effects of Tetrahydrobiopterin on Limb Blood Flow and Muscle Metabolism in Patients with COPD

ISMRM Annual Meeting

Montreal, Quebec

2019


#### Effects of High-Intensity Interval Training on Postprandial Lipemia and Glycemia

Texas ACSM

College Station, Texas

2016


#### Effects of Hot and Temperate Environments on Executive Function Tasks During Moderate and Intense Exercise

SFASU Undergraduate Research Conference

Nacogdoches, Texas

2014

# Teaching

## Row {data-height="75"}

### University of Utah


##### Biol 2420 - Human Physiology*


## Row {data-height="200"}

### University of Massachusetts Amherst


##### KIN 272 - Anatatomy and Physiology II*

##### Kin 470 - Exercise Physiology Lab

##### KIN 270 - Anatatomy and Physiology I Lab

##### Kin 570 - Advanced Exercise Physiology

##### Kin 110 - Human Performance and Nutrition


## Row {data-height="150"}

### Stephen F. Austin State University


##### Kin 100 - Physical Fitness Concepts and Activities*


##### KIN 120 - Foundations of Kinesiology*


##### KIN 200 - Fitness Activites for Life*


## Row {data-height="20"}

### American Red Cross

##### American Red Cross CPR and Lifeguarding Instructor*


## Row {data-height="20"}

\* Denotes Instructor of Record



# CV

### {data-height="700"}

```{r}
library(htmltools)

htmltools::tags$iframe(src = './data/DeckerS_CV.pdf', style='width:100%; height: 600px')

```